Postdoctoral Researcher - Experimental Hematology and Functional Genomics 80-100%

USZ Campus

Starting date: To be determined

The Boettcher Lab, led by Prof. Dr. med. Steffen Boettcher, is seeking a highly motivated and talented Postdoctoral Researcher to join our team at the Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, affiliated with the Comprehensive Cancer Center Zurich (CCCZ).
Our laboratory investigates fundamental molecular mechanisms of normal and malignant hematopoiesis, with a particular focus on hematopoietic stem cell biology, clonal hematopoiesis, and leukemogenesis. We combine cutting-edge molecular and cellular technologies, functional genomics, and preclinical disease models to address biologically and clinically relevant questions.
The successful candidate will take a leading role in an innovative research project investigating molecular mechanisms of hematopoietic stem cell dysfunction, with the long-term goal of identifying novel therapeutic opportunities for patients with inherited bone marrow failure.

Your responsibilities

Independently design, coordinate, and perform experimental research projects.
Establish and characterize advanced in vitro and in vivo disease models.
Develop and apply CRISPR-based genome editing and functional genomics approaches.
Conduct mechanistic investigations using molecular and cellular techniques.
Analyze and interpret complex experimental datasets.
Supervise and mentor junior researchers and students.
Contribute to scientific publications and presentations at international conferences.

Your profile

PhD in molecular biology, biomedical sciences, genetics, cancer biology, or a related discipline.
Strong experimental background in molecular and cellular biology.
Experience in genome editing, functional genomics, or stem cell biology is highly desirable.
Experience with preclinical models, next-generation sequencing, or high-throughput screening is an advantage.
A strong publication record appropriate to career stage.
Scientific curiosity, creativity, independence, and excellent organizational skills.
Excellent communication skills and fluency in English.

We offer

A fully funded position for 3 - 4 years, with salary and employment conditions in accordance with the guidelines of the Swiss National Science Foundation (SNSF).
An exciting research project at the interface of basic and translational hematology.
A stimulating, collaborative, and international scientific environment within the Boettcher Lab, Department of Medical Oncology and Hematology at the University Hospital Zurich / University of Zurich, and the Comprehensive Cancer Center Zurich (CCCZ).
Access to state-of-the-art technologies and research infrastructure.
Opportunities for scientific independence, professional development, and career advancement.
Close collaboration with experienced scientists and clinician-researchers.
Opportunities to publish in leading scientific journals and present at international conferences.

Application

Please submit your CV, publication list, a short motivation letter describing your research interests and experience, and contact details of at least two referees.

Principal Investigator: Prof. Dr. med. Steffen Boettcher
Lab website: https://www.boettcherlab.com/